Recruitment to the CHRONOS study is currently closed

  • A clinical trial investigating the outcomes of new prostate preserving surgery against whole prostate treatment

Why is CHRONOS happening?

  • Over 47,000 men in the UK are diagnosed with prostate cancer year, with more men being diagnosed every year

  • Prostate cancer progresses at various rates depending upon the type, grade and stage of cancer

  • Traditional whole prostate treatments are effective at curing cancer, however can cause significant urinary and erectile problems in 30-60% of men

  • New treatments focused directly to prostate cancer show promising results but have not been directly compared to traditional treatments

What treatments are available for prostate cancer?

  • Prostatectomy

    Typically performed as keyhole (laparoscopic or robot assisted) surgery

    Usually requires one hospital visit and an overnight stay in hospital, sometimes 1-3 nights

    Disease free (recurrence free) survival - 99.1% over 10 years

    Overall survival is 99.9% over 10 years

    Urinary leakage occurs in 5-20% and erectile dysfunction occurs in 40-60% of cases

  • Radiotherapy

    Typically performed as multiple day visits to the local radiotherapy centre

    Brachytherapy and sometimes radiotherapy require a procedure under general anaesthetic

    Disease free (recurrence free) survival is 99.1% over 10 years

    Overall survival is 99.9% over 10 years

    Urinary leakage occurs in 5-10% and erectile dysfunction occurs in 40-60% of cases

  • Focal Therapy

    Cryotherapy freezes targeted areas of the prostate, HIFU heats targeted areas to up to 80°

    Cryotherapy and HIFU are available in the NHS

    Disease free (recurrence free) survival is 80-90% over 5 years

    Overall survival is 96.0% over 5 years

    Both are performed as a day case procedure, normally under general anaesthetic

 

"There are many established and new treatments for localised prostate cancer. Currently we do not know how most of these treatments compare against each other, in terms of cancer control and side-effect profiles."

Miss Deepika Reddy
CHRONOS Trial Co-Ordinator

  • CHRONOS Centres

    Imperial College NHS Healthcare Trust

    University Hospital Southampton NHS Foundation Trust

    Sunderland Royal Hospital (opening soon)

    Ashford and St Peter's Hospitals

    The Royal Marsden NHS Foundation Trust (opening soon)

    Kingston Hospital NHS Foundation Trust (opening soon)

  • You are eligible if you:

    Have been diagnosed with localised intermediate risk prostate cancer

    Have been recommended treatment by your clinician

    Are over 18 years of age

    Are in good health

    Have not yet received treatment for your prostate cancer

“I had the emerging new procedure of HIFU...and have benefitted a great deal. Following on from my treatment it’s been a great privilege to help at the outset of a new trial like CHRONOS. It’s excellent to see how patient's involvement is such a valued part of things.”

Chris Dobbs
CHRONOS Patient Representative

  • Publications

    Early-Medium-Term Outcomes of Primary Focal Cryotherapy to Treat Nonmetastatic Clinically Significant Prostate Cancer from a Prospective Multicentre Registry

    Focal HIFU therapy in treatment of prostate cancer: a UK Multicentre series

    Reddy et al. IP-4 CHRONOS is launched. BJU International

  • Trial Registration

    ISRCTN 17796995

    clinicaltrials.gov identifier: NCT04049747

    EudraCT Number:2019-001365-32

    NIHR No. CPMS 41979

  • Chief Investigator
    Prof. Hashim U. Ahmed

    CHRONOS National Clinical Research Fellow & Sub-Investigator
    Miss Deepika Reddy BSc MRCS

    Sub-Investigator
    Mr Taimur Shah MBBS MRCS

    National Trial Manager
    Mr Thiagarajah Sasikaran